Immunomodulatory activity of extracellular heat shock proteins and their autoantibodies
نویسندگان
چکیده
منابع مشابه
HDAC Inhibitors and Heat Shock Proteins (Hsps)
Epigenetic alterations, including DNA acetylation, hypermethylation and hypomethylation, and the associated transcriptional changes of the affected genes are central to the evolution and progression of various human cancers, including pancreatic cancer. Cancer-associated epigenetic alterations are attractive therapeutic targets because such epigenetic alterations, unlike genetic changes, are po...
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Disease suppressive T cell regulation may depend on cognate interactions of regulatory T cells with self-antigens that are abundantly expressed in the inflamed tissues. Heat shock proteins (HSPs) are by their nature upregulated in stressed cells and therefore abundantly present as potential targets for such regulation. HSP immunizations have led to inhibition of experimentally induced inflammat...
متن کاملHeat Shock Proteins and their clinical Implications
Knowledge of the physiological role of heat shock proteins is currently limited; however better understanding of their function and thereby the acquisition of the capacity to harness their power might lead to their use as therapeutic agents and revolutionize clinical practice in a number of areas. Future work is needed to translate the experimental data on the capacity of heat shock proteins to...
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PURPOSE To identify the low-molecular-weight retinal proteins that are the targets of serum autoantibodies in patients with glaucoma and to study the ability of these antibodies to induce retinal apoptosis. METHODS Serum immunoreactivity against retinal proteins was examined in age-matched groups of 60 patients with normal-pressure glaucoma, 36 patients with high-pressure glaucoma, and a cont...
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As all biologists appreciate, there is constant interaction between life and the environment, and temperature plays a critical role. It establishes distribution limits, it affects rates of function as well as the survival of organisms. Notoriously sensitive to temperature is plant growth. Critical steps in plant life such as germination, flowering and breaking of dormancy can be manipulated by ...
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ژورنال
عنوان ژورنال: Microbiology and Immunology
سال: 2010
ISSN: 0385-5600,1348-0421
DOI: 10.1111/j.1348-0421.2010.00214.x